CHARLES M. PETERSON, M.D., F.A.C.P.; ROBERT L. JONES, M.D.; RONALD J. KOENIG, B.S.; ELLEN T. MELVIN, M.D.; MARK L. LEHRMAN, M.D.
Seven patients with diabetes mellitus were hospitalized and their blood sugar concentrations regulated as a result of fasting blood sugar, sugar around meals, urinary sugar, and hemoglobin AIc assays. Erythrocyte half-life as measured by 51Cr increased in all patients from a mean of 27 days to 31 days, while hemoglobin AIc levels decreased from a mean of 10.1% to 5.6%. Leukocyte adherence increased in all patients from a mean of 28% to 51%. Most striking were the changes observed in platelet function in response to epinephrine. The length of the secondary lag phase of platelet aggregation, after a stimulus with final concentration of 70 µM of epinephrine, increased from a mean of 19 seconds to 65 seconds. Studies in additional patients confirmed an inverse correlation between hemoglobin AIc concentration and the secondary lag phase (r = 0.87, P < 0.001). These studies found that certain secondary sequelae of diabetes can be corrected by strict carbohydrate control and confirmed that hemoglobin AIc assays provide a useful means of showing the degree of control of glucose metabolism in diabetic patients.
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PETERSON CM, JONES RL, KOENIG RJ, MELVIN ET, LEHRMAN ML. Reversible Hematologic Sequelae of Diabetes Mellitus. Ann Intern Med. 1977;86:425–429. doi: 10.7326/0003-4819-86-4-425
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Published: Ann Intern Med. 1977;86(4):425-429.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism, Hematology/Oncology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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