K. LEO BUXBAUM, M.D.
To the editor: The paper on naloxone by Dr. Martin (Ann Intern Med 85:765-768, 1976) states on page 767, "Naloxone has a relatively short duration of action. The serum half-life of naloxone is just over an hour (17) and the half-life of commonly used clinical doses may be only several hours (18, 19)."
By definition, the half-life of any substance X is constant and most certainly does not depend on the initial dose. This is such a serious conceptual error that it undermines my confidence in the whole paper.
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BUXBAUM KL. Naloxone Half-Life. Ann Intern Med. 1977;86:506–507. doi: 10.7326/0003-4819-86-4-506_2
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Published: Ann Intern Med. 1977;86(4):506-507.
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