J. L. MOAKE, M.D.; W. V. KAGELER, M.D.; P. L. CIMO, M.D.; R. W. BLAKELY, M.D.; R. D. ROSSEN, M.D.; W. HAESSE, M.D.
MOAKE JL, KAGELER WV, CIMO PL, BLAKELY RW, ROSSEN RD, HAESSE W. Intravascular Hemolysis, Thrombocytopenia, Leukopenia, and Circulating Immune Complexes after Jejunal-Ileal Bypass Surgery. Ann Intern Med. 1977;86:576-578. doi: 10.7326/0003-4819-86-5-576
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Published: Ann Intern Med. 1977;86(5):576-578.
Two years after jejunal-ileal bypass surgery for obesity, a 25-year-old man developed intravascular hemolysis, thrombocytopenia, and neutropenia. The patient's erythrocytes were coated with complement components (C4/C3) and his serum induced complement-dependent immune lysis of chromium-51-labeled platelets. Serum [125I]-C1q binding activity (a measure of the presence of immune complexes) was increased, and serum C4 and C3 hemolytic titers were depressed. Immune complex-mediated complement activation apparently accounted for the blood cell destruction in this patient.
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Gastroenterology/Hepatology, Hematology/Oncology, Platelet Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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