STEVEN D. REICH, M.D.
To the editor: The use of amphotericin B as a sensitizing agent during combination chemotherapy in human neoplasia has been reported by Presant, Klahr, and Santala (1). An implication of the lack of an important control population in this study deserves comment.
The commercial preparation of amphotericin B, Fungizone® (E. R. Squibb, Princeton, New Jersey), is prepared with 41 mg of sodium deoxycholate to every 50 mg of amphotericin B. The deoxycholate is used to form a colloidal dispersion because crystalline amphotericin B is insoluble in water. Both amphotericin B and deoxycholate have cell-membrane altering effects that can increase the
Learn more about subscription options.
Register Now for a free account.
REICH SD. Deoxycholate or Amphotericin B in Chemotherapy Sensitization. Ann Intern Med. 1977;86:656–657. doi: 10.7326/0003-4819-86-5-656
Download citation file:
Published: Ann Intern Med. 1977;86(5):656-657.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only