EDWARD CHIRITO, M.D.
To the editor: The review article "Hematologic Aspects of Systemic Lupus Erythematosus" by Budman and Steinberg (Ann Intern Med 86:220-229, 1977) omits mention of the bone marrow as a target organ in the disease. Rosen and associates (1) have reported five patients with the bone-marrow morphologic features of myelofibrosis in association with the lupus erythematosus cell phenomenon. In addition, all five had antinuclear antibodies in the serum, and two had a positive direct antiglobulin reaction (Coombs' Test). Clinically, four were female, four had unexplained fever, and two arthralgia. Only one patient was under age 50 and none manifested the classical
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CHIRITO E. Bone Marrow in Lupus Erythematosus. Ann Intern Med. 1977;86:831–832. doi: 10.7326/0003-4819-86-6-831_2
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Published: Ann Intern Med. 1977;86(6):831-832.
Lupus Erythematosus, Rheumatology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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