KENNETH I. SHINE, M.D.; ALAN M. FOGELMAN, M.D.; ALBERT A. KATTUS, M.D., F.A.C.P.; GERALD D. BUCKBERG, M.D.; JAN H. TILLISCH, M.D., F.A.C.P.
Primary prevention of death from ischemic heart disease requires further understanding of the pathogenesis of this disorder. Cellular defects of cholesterol metabolism may be more significant markers than serum lipid levels for the identification and treatment of atherosclerotic risk. Coronary spasm has been shown to be an important cause of ischemia in the presence and absence of atherosclerotic lesions. Careful manipulation of physiologic variables with vasodilator agents during cardiopulmonary bypass can substantially alter the myocardial oxygen supply-demand relation, thereby minimizing ischemic injury. The cellular basis for loss of mechanical function during ischemia and the factors that determine irreversible injury are yet unknown.
Learn more about subscription options.
Register Now for a free account.
SHINE KI, FOGELMAN AM, KATTUS AA, BUCKBERG GD, TILLISCH JH. Pathophysiology of Myocardial Infarction. Ann Intern Med. 1977;87:75–85. doi: 10.7326/0003-4819-87-1-75
Download citation file:
Published: Ann Intern Med. 1977;87(1):75-85.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only