M. ELAINE EYSTER, M.D., F.A.C.P.; HERBERT S. BOWMAN, M.D., F.A.C.P.; JUDY N. HAVERSTICK, R.N.
This content is PDF only. Please click on the PDF icon to access.
To the editor: In a 15-month period during which time 4 700 000 units of factor VIII were used by 70 hemophiliacs known to us, fifteen adverse reactions were reported. Excluding surgical use, this represents an average of 40 000 factor VIII units per patient treated per year. Ten reactions occurred in 53 patients (19%) receiving freeze-dried concentrates; five occurred in 17 patients (29%) receiving cryoprecipitate.
Anaphylactoid reactions consisting of severe bronchospasm, dyspnea, and substernal pain or hypotension, or both, occurred in five patients, four of whom received concentrates and one of whom received cryoprecipitate. All responded promptly to adrenalin
Learn more about subscription options.
Register Now for a free account.
EYSTER ME, BOWMAN HS, HAVERSTICK JN. Adverse Reactions to Factor VIII Infusions. Ann Intern Med. 1977;87:248. doi: 10.7326/0003-4819-87-2-248_1
Download citation file:
Published: Ann Intern Med. 1977;87(2):248.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only