BASIL I. HIRSCHOWITZ, M.D., F.A.C.P., F.R.C.P., F.R.C.P. (EDIN)
HIRSCHOWITZ BI. Histamine H-2 Receptor Antagonists. Ann Intern Med. 1977;87:373-375. doi: 10.7326/0003-4819-87-3-373
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Published: Ann Intern Med. 1977;87(3):373-375.
The actions of histamine are mediated by two types of receptors that are present on a number of morphologically distinct cell types (1). Those mediating mepyramine-sensitive histamine responses are defined as H-1 receptors. H-2 receptors, which mediate histamine effects on gastric acid secretion, cardiac pacemaker, and a growing list of other actions (1), are blocked by a new class of compounds first synthesized by Black and colleagues (2). They have also described specific agonists for H-1 (2-methyl histamine) and H-2 (4-methyl histamine) receptors. These and newer H-1 and H-2 specific agonists and antagonists have been used in a large number
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