RIDA A. FRAYHA, M.D.
FRAYHA RA. Colchicine in Familial Mediterranean Fever. Ann Intern Med. 1977;87:382. doi: 10.7326/0003-4819-87-3-382_2
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Published: Ann Intern Med. 1977;87(3):382.
To the editor: The cause and pathogenesis of familial Mediterranean fever (FMF) are not clear, hence treatment, by necessity, has been empirical. Prophylactic colchicine therapy has recently been shown to be highly effective in preventing the attacks by suppressing the inflammatory reaction and its symptoms without affecting the basic biorhythm or the underlying excitatory process (1, 2). The mechanism of action of colchicine in FMF remains unclear. Colchicine is known to disrupt the intracellular microtubular structures and to interfere with cellular motility and division. Dinarello and associates (3) have recently shown that patients with FMF on colchicine have significantly fewer
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