DAVID T. KIANG, M.D., Ph.D.; BJ. KENNEDY, M.D.
KIANG DT, KENNEDY B. Tamoxifen (Antiestrogen) Therapy in Advanced Breast Cancer. Ann Intern Med. 1977;87:687-690. doi: 10.7326/0003-4819-87-6-687
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Published: Ann Intern Med. 1977;87(6):687-690.
Fifty-nine postmenopausal women with advanced breast cancer were treated with tamoxifen (antiestrogen), 20 mg orally twice a day for at least 2 months. They had been previously treated with other types of hormonal therapy or intensive chemotherapies, or both. Nineteen of the 59 patients (32%) had either a complete response (seven patients) or partial response (12 patients). The median duration of response was 9 + months. Tumors containing estrogen receptors and those that responded to previous hormonal manipulation tended to respond to tamoxifen (60% and 69%, respectively). Patients with receptor-negative tumor or with a history of failure of previous hormonal treatments did not respond to tamoxifen therapy. Tamoxifen is effective against advanced breast cancer. Side effects of the treatment were mild.
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Breast Cancer, Hematology/Oncology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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