THOMAS J. LAWLEY, M.D.; GARY L. PECK, M.D.; HARALAMPOS M. MOUTSOPOULOS, M.D.; ALOIS A. GRATWOHL, M.D.; ALBERT B. DEISSEROTH, M.D., Ph.D.
LAWLEY TJ, PECK GL, MOUTSOPOULOS HM, GRATWOHL AA, DEISSEROTH AB. Scleroderma, Sjögren-like Syndrome, and Chronic Graft-Versus-Host Disease. Ann Intern Med. 1977;87:707-709. doi: 10.7326/0003-4819-87-6-707
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Published: Ann Intern Med. 1977;87(6):707-709.
A patient with acute myelogenous leukemia treated with an allogeneic bone marrow transplant developed acute graft-versus-host disease manifested by severe diarrhea, hepatitis, and a cutaneous eruption. As the graft-versus-host disease progressed to the chronic phase, the patient developed marked cutaneous sclerosis and symptoms of xerophthalmia and xerostomia. Biopsy of his indurated skin showed features of both graft-versus-host disease and scleroderma. Results of Schirmer's tests, corneal fluorescent studies, parotid flow-rate testing, and a lip biopsy were consistent with Sjögren's syndrome. Possibly, activated lymphocytes may have a role in the pathogenesis of graft-versus-host disease, scleroderma, and Sjögren's syndrome.
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