R. B. LIVINGSTON, M.D.; T. N. MOORE, M.D.; L HEILBRUN, M.D.; R. BOTTOMLEY, M.D.; D. LEHANE, M.D.; S. E. RIVKIN, M.D.; T. THIGPEN, M.D.
Chemotherapy (doxorubicin, cyclophosphamide, and vincristine) was given in a sequential fashion with radiation of the primary tumor and brain to 358 patients with small-cell lung carcinoma (extensive disease in 250, limited in 108). Complete regression of tumor was obtained in 14% of patients with extensive disease and 41% of patients with limited disease, and complete or partial response in 57% and 75%, respectively. Median survival was 26 weeks for patients with extensive disease and 52 weeks for those with limited disease. Response duration was longer for patients in complete remission; one third had disease-free survival > 1 year. Toxicity from the combined treatment modalities was no greater than expected from the components given separately: fatal in 3.9%, and life-threatening but reversible in 8.4% of patients. Whole-brain radiation was effective in preventing isolated relapse at that site. This therapy appears both feasible and effective, with acceptable risks and some benefit to most patients.
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LIVINGSTON RB, MOORE TN, HEILBRUN L, BOTTOMLEY R, LEHANE D, RIVKIN SE, et al. Small-Cell Carcinoma of the Lung: Combined Chemotherapy and Radiation: A Southwest Oncology Group Study. Ann Intern Med. 1978;88:194–199. doi: 10.7326/0003-4819-88-2-194
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Published: Ann Intern Med. 1978;88(2):194-199.
Hematology/Oncology, Lung Cancer, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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