JAY SILVERBERG, M.D., F.R.C.P.(C); VAS V. ROW, M.A., M.SC.; ROBERT VOLPÉ, M.D., F.R.C.P.(C), F.A.C.P.
Currently, Graves' disease is considered to have an immune basis (1). Numerous disturbances in cellular and humoral immunity have been documented in patients with Graves' disease; some such changes are specific, whereas others have been nonspecific. Rheumatoid factors are a family of antiglobulins directed against the Fc' fragment of human IgG molecules (2). Classically rheumatoid factors are detected in the serum of patients with rheumatoid arthritis; however, they may be found in the serum of patients with other disorders in which the immune system plays some role (3). Normal persons, especially the elderly, may also have low titres of rheumatoid
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SILVERBERG J, ROW VV, VOLPÉ R. Rheumatoid Factors in Graves' Disease. Ann Intern Med. 1978;88:216-217. doi: 10.7326/0003-4819-88-2-216
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Published: Ann Intern Med. 1978;88(2):216-217.
Endocrine and Metabolism, Thyroid Disorders.
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