NOEL S. WEISS, M.D.
▸Requests for reprints should be addressed to Noel S. Weiss, M.D.; Department of Epidemiology, SC-36, University of Washington; Seattle, WA 98195.
WEISS N.; Noncontraceptive Estrogens and Abnormalities of Endometrial Proliferation. Ann Intern Med. 1978;88:410-412. doi: 10.7326/0003-4819-88-3-410
Download citation file:
Published: Ann Intern Med. 1978;88(3):410-412.
Use of estrogen preparations among menopausal women has been causally associated with the development of hyperplasia and adenocarcinoma of the endometrium. The magnitude of the association seems to be greater for the hyperplastic and least aggressive malignant lesions, and smaller for tumors of higher stage and grade. This observed inverse relation of estrogen use to degree of malignancy is probably due to relatively early or overly liberal diagnoses of endometrial cancer among estrogen users, but could mean simply that estrogens promote less aggressive tumors. It appears the current increased incidence of endometrial cancer in the United States will not be followed by a corresponding increase in mortality from the disease.
to gain full access to the content and tools.
Learn more about subscription options.
Register Now for a free account.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only