A. FONTANA, M.D.; P. J. GROB, M.D.
FONTANA A, GROB PJ. Immunoglobulin Deficiency, HLA Antigens, and Seizures. Ann Intern Med. 1978;88:429. doi: 10.7326/0003-4819-88-3-429_2
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Published: Ann Intern Med. 1978;88(3):429.
To the editor: In the January 1977 issue Van Thiel and associates (1) reported on "A Syndrome of Immunoglobulin A Deficiency, Diabetes Mellitus, Malabsorption, and a Common HLA Haplotype." We wish to emphasize further a remarkable feature present in two of the three reported cases: Patient 12 was "on at least two occasions . . . hospitalized for a seizure disorder that may have been related to difficulties in managing her diabetes in the presence of malabsorption"; and Patient 17 had so-called idiopathic epilepsy.
We have recently reported on the association of IgA deficiency with epilepsy. Measurement of the IgA
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