Psychobiology and Human Disease.. Ann Intern Med. 1978;88:441. doi: 10.7326/0003-4819-88-3-441_1
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Published: Ann Intern Med. 1978;88(3):441.
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Weiner's goal is to develop integrative, multifactoral models of disease etiology. He has approached this by preparing comprehensive reviews of findings from genetic, biochemical, physiological, psychosomatic, and epidemiological studies of seven diseases: essential hypertension, peptic ulcers, bronchial asthma, rheumatoid arthritis, Grave's disease, ulcerative colitis, and regional enteritis.
The multiple pathophysiological processes involved in each disease are described, with emphasis on the wide variation in physiological patterns in different patients who are said to have the same disease (for example, the extremely diverse patterns of aldosterone and renin secretion in different patients with essential hypertension). Weiner stresses that these different physiological
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