JEFFREY G. ROTHMAN, M.D.; PETER J. SNYDER, M.D.; ROBERT D. UTIGER, M.D.
ROTHMAN JG, SNYDER PJ, UTIGER RD. Hypothalamic Endocrinopathy in Hand-Schüller-Christian Disease. Ann Intern Med. 1978;88:512-513. doi: 10.7326/0003-4819-88-4-512
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Published: Ann Intern Med. 1978;88(4):512-513.
Hand-SchÜller-Christian disease is characterized by infiltration of multiple organs by well-differentiated histiocytes. Diabetes insipidus is a well-known manifestation of this disease, and anterior pituitary hormone deficiencies also occur (1). We describe a patient with Hand-Schüller-Christian disease whose hypothalamic-pituitary function was tested extensively. The results support the hypothesis that Hand-Schüller-Christian disease causes a hypothalamic endocrinopathy.
A 19-year-old man was referred for evaluation of polyuria and a goiter. He also had progressive exertional dyspnea and left axillary and right inguinal skin lesions.
The thyroid was symmetrically enlarged, firm, and smooth, each lobe measuring 10 x 5 cm. There were several left axillary
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Endocrine and Metabolism, Neurology, Pulmonary/Critical Care, Interstitial Lung Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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