DAVID P. L. SACHS, M.D.; ROBERT G. HALL, Ph.D.; SHARON M. HALL, Ph.D.
SACHS DPL, HALL RG, HALL SM. Effects of Rapid Smoking: Physiologic Evaluation of a Smoking-Cessation Therapy. Ann Intern Med. 1978;88:639-641. doi: 10.7326/0003-4819-88-5-639
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Published: Ann Intern Med. 1978;88(5):639-641.
We studied 24 healthy young male smokers to ascertain the medical safety of a highly effective smoking-abatement technique called rapid smoking. In comparison with results obtained after a 12-h cigarette fast or after normal smoking, statistically significant increases occurred after rapid smoking in heart and respiratory rates, systolic blood pressure, carboxyhemoglobin, and pH (p < 0.05), while arterial PCO2, HCO3, and serum [K+] fell (p < 0.05). Rapid smoking produced alveolar hyperventilation in all subjects. In eight, arterial PO2 increased appropriately, but in 16, fell paradoxically (p < 0.01); seven had arterial PO2 below 80 torr. Because this fall could represent ventilation/perfusion mismatch due to early bronchoconstrictive disease, in subjects with normal flow/volume loops and spirometry rapid smoking may be a simple, provocative screening test for early airway disease. Despite the changes produced there were no arrhythmias. Rapid smoking is safe for healthy subjects but should not now be used for higher-risk patients.
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Cardiology, Coronary Risk Factors, Prevention/Screening, Smoking, Tobacco, Alcohol, and Other Substance Abuse.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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