MICHAEL A. RIE, M.D., F.A.C.P.; ROGER S. WILSON, M.D.
Cardiovascular dysfunction is a well-recognized complication of generalized tetanus in man (1, 2). Both alpha and beta adrenergic blocking agents have been advocated to control arrhythmias and decrease the extreme fluctuations in systemic blood pressure (3). Prys-Roberts and associates (3) reported successful control of sympathetic overactivity with inhalation anesthetics but stressed that toxic effects limited their usefulness. The following case of severe generalized tetanus in the adult associated with autonomic hyperactivity shows successful management with large doses of intravenous morphine.
A 43-year-old previously healthy male construction worker developed trismus, generalized seizures, and upper airway obstruction 8 days after lacerating his
Learn more about subscription options.
Register Now for a free account.
RIE MA, WILSON RS. Morphine Therapy Controls Autonomic Hyperactivity in Tetanus. Ann Intern Med. 1978;88:653–654. doi: 10.7326/0003-4819-88-5-653
Download citation file:
Published: Ann Intern Med. 1978;88(5):653-654.
Infectious Disease, Tobacco, Alcohol, and Other Substance Abuse.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only