ENGRACIO P. CORTES, M.D.; MARK D. LIPSHUTZ, M.D.
CORTES EP, LIPSHUTZ MD. Hormonal Therapy of Breast Cancer. Ann Intern Med. 1978;88:844. doi: 10.7326/0003-4819-88-6-844_2
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Published: Ann Intern Med. 1978;88(6):844.
To the editor: The excellent review of Legha, Davis, and Muggia, "Hormonal Therapy of Breast Cancer: New Approaches and Concepts" (Ann Intern Med 88:69-77, 1978) failed to mention two critical clinical phenomena.
First, about 25% of postmenopausal patients with metastatic breast cancer who previously responded to estrogen therapy have a second objective remission when the hormone is withdrawn without further treatment (1, 2). This phenomenon is called rebound regression or hormone withdrawal effect and has been recognized since 1949 (3). The duration of response usually varies from 3 to 39 months. One should therefore hesitate to recommend immediate adrenalectomy or
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