MARCEL E. CONRAD, M.D.; ROBERT G. KNODELL, M.D.
CONRAD ME, KNODELL RG. Gamma Globulin and Non-A Type Hepatitis. Ann Intern Med. 1978;89:141-142. doi: 10.7326/0003-4819-89-1-141
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Published: Ann Intern Med. 1978;89(1):141-142.
To the editor: In the March issue the VA Cooperative Study Group elegantly showed that hepatitis B immune globulin (HBIG) is superior to immune serum globulin (ISG) in preventing hepatitis type B among persons exposed by needle stick to HBsAG (1). However, they incorrectly stated that it was impossible to determine whether ISG has any efficacy in the prevention of hepatitis type B because a non-gamma globulin placebo has not been used in any clinical trial. The first gamma globulin trial in which HBsAg testing was available was a randomized, double-blind study of 107 803 subjects in which the efficacy
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