JOHN OWEN, M.D.; EREN PAYNE, R.T.; KELVIN CARSTAIRS, M.B.
OWEN J, PAYNE E, CARSTAIRS K. Erroneous Activated Partial Thromboplastin Time. Ann Intern Med. 1978;89:146-147. doi: 10.7326/0003-4819-89-1-146_2
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Published: Ann Intern Med. 1978;89(1):146-147.
To the editor: We wish to draw attention to the problem of erroneous results of activated partial thromboplastin times (aPTT) when plasma samples from patients on heparin are tested with the Lancer CoagulyzerTm. The errors can be large enough to interfere with appropriate therapy.
The Coagulyzer is an automated clot detector with a turntable capable of holding 60 samples, and it has two automatic reagent pipettes, positioned eight stations apart; six of these are heated to 37 °C. When the machine is set to the aPTT mode, the first pipette delivers the aPTT reagent (in our laboratory, General Diagnostics [Morris
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