FREDERICK M. VINCENT, M.D.; SCOTT EMERY, M.D.
VINCENT FM, EMERY S. Antidiuretic Hormone Syndrome and Thioridazine. Ann Intern Med. 1978;89:147-148. doi: 10.7326/0003-4819-89-1-147_3
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Published: Ann Intern Med. 1978;89(1):147-148.
To the editor: The article "Inappropriate Antidiuresis During Carbamazepine Treatment" (Ann Intern Med 87:722-723, 1977) warns us of a potentially serious complication of a fairly widely used medication. We wish to report the case of a psychiatric patient who developed the syndrome of inappropriate antidiuretic hormone secretion (SIADH) after the administration of thioridazine (Mellaril®).
A 58-year-old woman was admitted to the hospital for treatment of her chronic depression. She was taking amitriptyline hydrochloride, 150 mg daily. On admission her blood urea nitrogen (BUN) was 9 mg/dl; serum sodium concentration, 139 meq/litre; and urine specific gravity, 1.012. Her amitriptyline dosage was
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