ROBERT G. DLUHY, M.D.; THOMAS J. MOORE, M.D.; GORDON H. WILLIAMS, M.D., F.A.C.P.
Sella turcica enlargement is a well-established complication of prolonged, primary hypothyroidism (1, 2). Because enlargement of the sella turcica has also been reported in untreated patients with primary gonadal insufficiency (for example, Klinefelter's and Turner's syndromes) (3, 4), it has been hypothesized that prolonged target-hormone insufficiency may lead to hyperplastic or adenomatous transformation of the pituitary trophic cells. Our report adds evidence for this hypothesis, documenting for the first time sella turcica enlargement in two patients with primary adrenal insufficiency.
Patient 1: A 21-year-old man presented in 1939 with a 2-year history of increasing skin pigmentation, salt-craving, and a 16-kg
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DLUHY RG, MOORE TJ, WILLIAMS GH. Sella Turcica Enlargement and Primary Adrenal Insufficiency. Ann Intern Med. 1978;89:513-514. doi: 10.7326/0003-4819-89-4-513
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Published: Ann Intern Med. 1978;89(4):513-514.
Adrenal Disorders, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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