DAVID D. STUART, M.D.; ALVIN L. SCHULTZ, M.D., F.A.C.P.
The liver may be a major site of extrathyroidal conversion of thyroxine (T4) to triiodothyronine (T3). Patients with alcoholic liver disease of several types have been observed to have mild but significant elevations of serum thyrotropin (TSH) and free T4, and normal or low free T3 compared with control populations (1, 2). Estimated T3 production rate in patients with hepatic cirrhosis is substantially less than that of normal persons, whereas the production rate of reverse T3 is unchanged (3). These observations suggest that, in patients with liver disease, a compensatory increase in TSH and in thyroidal hormonogenesis occurs in response
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STUART DD, SCHULTZ AL. Thyroid Function Tests Simulating Graves' Disease in Alcoholic Hepatitis. Ann Intern Med. 1978;89:514–515. doi: 10.7326/0003-4819-89-4-514
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Published: Ann Intern Med. 1978;89(4):514-515.
Endocrine and Metabolism, Thyroid Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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