DAN STREJA, M.D.; GEORGE STEINER, M.D.; PETER O. KWITEROVICH, M.D.
Grant support: by the Ontario Heart Foundation and Contract NO1-HV-12158-L from the National Heart, Lung, and Blood Institute. Dr. Streja is a former Fellow of the Ontario Heart Foundation.
▸Requests for reprints should be addressed to Peter O. Kwiterovich, Jr., M.D.; Johns Hopkins Hospital, 600 N. Wolfe St.; Baltimore, MD 21205.
STREJA D., STEINER G., KWITEROVICH P.; Plasma High-Density Lipoproteins and Ischemic Heart Disease: Studies in a Large Kindred with Familial Hypercholesterolemia. Ann Intern Med. 1978;89:871-880. doi: 10.7326/0003-4819-89-6-871
Download citation file:
Published: Ann Intern Med. 1978;89(6):871-880.
The expression of ischemic heart disease was studied in a large kindred with familial hypercholesterolemia. Tendon xanthomas, multiple generation transmission, and the appearance of bimodality in the distributions of total and low-density lipoprotein cholesterol were found. The segregation ratio was 0.9 in females and 0.43 in males, a difference first apparent during adolescence. The upper quartile of total and low-density lipoprotein cholesterol contained all but two cases of ischemic disease, whereas the lower quartile of high-density lipoprotein cholesterol contained one half of the cases. The ratio of high- to low-density lipoprotein cholesterol (range, 0.06 to 1.6) was 0.20 in each patient with ischemic disease. The association of a low level of high-density lipoprotein cholesterol with ischemic disease persisted after adjustment for differences in other lipids and lipoproteins. A low level of high-density lipoprotein cholesterol, as well as a high level of low-density lipoprotein cholesterol, may influence the development of ischemic heart disease in this disorder.
to gain full access to the content and tools.
Learn more about subscription options.
Register Now for a free account.
Cardiology, Dyslipidemia, Coronary Risk Factors.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only