GARY L. LATTIMER, M.D.; LUTHER V. RHODES III, M.D.; JOHN S. SALVENTI, Ph.D.; JOHN P. GALGON, M.D.; VICTOR STONEBRAKER; SHARON BOLEY, B.S.; GARY HAAS
Clinical, pulmonary, and serologic findings in Legionnaires who attended the 1976 American Legion Convention in Philadelphia were studied 2 years after the Legionnaires' disease epidemic there. All 31 survivors of Legionnaires' disease studied became ill within 2 weeks after the convention, and 18 had not fully recovered 2 years after the epidemic. Twenty-five (28%) of 90 additional Legionnaires exposed at the convention but not diagnosed as having Legionnaires' disease became ill during the same time interval; five of these had symptoms during the next 2 years. Survivors had decreased diffusion capacities measured by the carbon monoxide single-breath method. These differences could not be accounted for by ventilation abnormalities or concurrent illness. Significant levels of IgG or IgM antibodies persisted in 94% of survivors of Legionnaires' disease and in 53% of Legionnaires exposed at the convention, which suggests a high prevalence of subclinical infection. Persistence of IgM antibody raises the question of latency or subclinical infection as part of the natural history of Legionnaires' disease.
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LATTIMER GL, RHODES LV, SALVENTI JS, GALGON JP, STONEBRAKER V, BOLEY S, et al. The Philadelphia Epidemic of Legionnaire's Disease: Clinical, Pulmonary, and Serologic Findings Two Years Later. Ann Intern Med. 1979;90:522–526. doi: 10.7326/0003-4819-90-4-522
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Published: Ann Intern Med. 1979;90(4):522-526.
Infectious Disease, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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