KENNETH W. HEDLUND, M.D.; VIRGINIA G. McGANN, Ph.D.; DIANA S. COPELAND, D.V.M.; STEPHEN F. LITTLE, B.S.; RICHARD G. ALLEN, Ph.D.
Female AKR/J mice were challenged with the Washington strain of Legionnaires' disease (LD) bacteria. Nonimmunized mice inoculated intraperitoneally with 2 X 108 colony forming units became ill within 4 h and died within 24 h. Progressive histopathologic changes initiated as early as 2 h after inoculation involved the lymphoid organs, the crypts of the small intestine, and the liver. Necrosis with minimal inflammatory cell reaction was the primary lesion. Immunization with a soluble LD bacterial antigen failed to prevent illness but protected against death and development of abnormal histologic changes.
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HEDLUND KW, McGANN VG, COPELAND DS, LITTLE SF, ALLEN RG. Immunologic Protection Against the Legionnaires' Disease Bacterium in the AKR/J Mouse. Ann Intern Med. 1979;90:676–679. doi: 10.7326/0003-4819-90-4-676
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Published: Ann Intern Med. 1979;90(4):676-679.
Infectious Disease, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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