RONALD J. FALLON, M.D.; WILLIAM H. ABRAHAM
Four-hundred fifty-nine sera from 342 persons were examined at Ruchill Hospital, Glasgow, using an agargrown heat-killed, ether-treated antigen derived from the Philadelphia 1 strain of the Legionnaires' disease bacterium. They were examined, in parallel, at the Center for Disease Control (CDC), Atlanta. Overall agreement (results agreeing ± one twofold dilution) was reached with 90% of sera. Important differences were obtained with 10 (2.2%) sera. With three of these 10 sera the CDC alone obtained a significant titre (256) whereas with the other seven the Glasgow laboratory alone obtained a titre of 256. Altogether 28 persons (8.2%) with an agreed titre of 256 or higher were identified. However, some of these people had been ill 4 years before serum was obtained for examination. These persistent high titres make the serologic diagnosis of Legionnaires' disease difficult.
Learn more about subscription options.
Register Now for a free account.
FALLON RJ, ABRAHAM WH. Scottish Experience with the Serologic Diagnosis of Legionnaires' Disease. Ann Intern Med. 1979;90:684–686. doi: 10.7326/0003-4819-90-4-684
Download citation file:
Published: Ann Intern Med. 1979;90(4):684-686.
Infectious Disease, Pulmonary/Critical Care.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only