RICHARD I. FISHER, M.D.; VINCENT T. DeVITA, M.D.; SUSAN P. HUBBARD, R.N.; RICHARD SIMON, Ph.D.; ROBERT C. YOUNG, M.D.
FISHER RI, DeVITA VT, HUBBARD SP, SIMON R, YOUNG RC. Prolonged Disease-Free Survival in Hodgkin's Disease with MOPP Reinduction After First Relapse. Ann Intern Med. 1979;90:761-763. doi: 10.7326/0003-4819-90-5-761
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Published: Ann Intern Med. 1979;90(5):761-763.
Thirty-two patients with Hodgkin's disease who relapsed after a first complete remission induced by nitrogen mustard, vincristine, procarbazine, and prednisone (MOPP) were retreated with MOPP chemotherapy. Nineteen patients achieved a second complete remission. Median duration of the second complete remission was 21 months. The likelihood of achieving a second complete response could be predicted by the duration of the first response. Fourteen of 15 patients whose first complete remission was longer than 12 months achieved a second complete response in contrast to five of 17 patients whose initial complete remission lasted less than 12 months (P < 0.001). Median survival of all patients in this study who were re-treated with MOPP was longer than 4 years after their first relapse. We conclude that patients with Hodgkin's disease who relapse after a first complete remission induced by MOPP are not necessarily resistant to further MOPP therapy and can achieve long-term survival with MOPP reinduction.
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