LAWRENCE PARKER, M.D.; ALEX KUTAS, M.D.; MICHAEL BOLOGNESE, M.D.; RONALD SKOWSKY, M.D.
To the editor: There are two major reasons to measure accurately the mineralocorticoid potency of a corticosteroid preparation. First, a corticosteroid must be used for its anti-inflammatory effect without inducing excessive sodium retention that causes edema and congestive heart failure. Second, the choice of replacement therapy in a patient with primary adrenal insufficiency depends on the ratio of glucocorticoid to mineralocorticoid activity. A corticosteroid preparation with little or no sodium-retaining properties must often be supplemented with a more potent mineralocorticoid to prevent hyperkalemia, hypotension, or vascular collapse.
Comparison of the reported mineralocorticoid potencies of some widely used corticosteroids, as listed
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PARKER L, KUTAS A, BOLOGNESE M, SKOWSKY R. References on Sodium-Retaining Potency of Corticosteroids. Ann Intern Med. 1979;90:853–854. doi: 10.7326/0003-4819-90-5-853_2
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Published: Ann Intern Med. 1979;90(5):853-854.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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