DAVID F. HUTCHEON, M.D.; THEODORE M. BAYLESS, M.D.; JOHN L. CAMERON, M.D.; STEPHEN B. BAYLIN, M.D.
A father and son each presented with severe watery diarrhea. The son was found to have a pancreatic islet-cell tumor associated with the pancreatic cholera syndrome, as well as a parathyroid adenoma. The father was found to have multiple islet-cell adenomas and the Zollinger-Ellison syndrome. Pancreatic tumor tissue from each patient contained detectable gastrin and vasoactive intestinal peptide; however, a much higher gastrin concentration was found in the tumor tissue from the father and a much higher vasoactive intestinal peptide content in the tumor tissue from the son. Thus, watery diarrhea may be mediated by different hormones in families having multiple endocrine neoplasia; the precise cause of the diarrheal syndrome should be defined to ensure the proper therapy.
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HUTCHEON DF, BAYLESS TM, CAMERON JL, BAYLIN SB. Hormone-Mediated Watery Diarrhea in a Family with Multiple Endocrine Neoplasms. Ann Intern Med. 1979;90:932–934. doi: 10.7326/0003-4819-90-6-932
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Published: Ann Intern Med. 1979;90(6):932-934.
Diarrhea, Endocrine and Metabolism, Endocrine Cancer, Gastroenterology/Hepatology, Hematology/Oncology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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