MAXIME SELIGMANN, M.D.; JEAN-CLAUDE BROUET, M.D.; MARYLINE SASPORTES, M.D.
SELIGMANN M, BROUET J, SASPORTES M. Hereditary C2 Deficiency Associated with Common Variable Immunodeficiency. Ann Intern Med. 1979;91:216-217. doi: 10.7326/0003-4819-91-2-216
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Published: Ann Intern Med. 1979;91(2):216-217.
Homozygous C2 deficiency in a 19-year-old boy was associated with variable immunodeficiency manifested by marked hypoimmunoglobulinemia and impaired antibody responses, normal circulating B lymphocytes, and subnormal T-cell functions. Neither antilymphocytic autoantibodies nor chromosomal abnormalities were found. Serum immunoglobulin levels were within normal limits in his parents and brother who were heterozygous for C2 deficiency. The patient's lymphocytes were homozygous at the HLA-D locus but expressed an antigen different from DW2.
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Hematology/Oncology, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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