ROBERT L. BREARLEY, M.B.; RAMONA M. CHAPMAN, M.D.; BRANCO BROZOVIC, Ph.D.
BREARLEY RL, CHAPMAN RM, BROZOVIC B. Hairy-Cell Leukemia Presenting as Aplastic Anemia. Ann Intern Med. 1979;91:228. doi: 10.7326/0003-4819-91-2-228
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Published: Ann Intern Med. 1979;91(2):228.
Hairy-cell leukemia typically presents with a reduction in normal peripheral blood cells and variable numbers of circulating mononuclear cells with prominent cytoplasmic projections. The blood changes are usually associated with effacement of bone-marrow architecture by a diffuse mononuclear cell infiltrate and a characteristic pattern of increased delicate fibrosis seen on marrow
biopsy (1-3). During the past 3 years, four patients with hairy-cell leukemia have been referred to our departments with peripheral blood cytopenias but bone-marrow hypoplasia of such degree that they were originally diagnosed as having aplastic anemia. This presentation has not been described previously.
Three patients presented with anemia
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Hematology/Oncology, Leukemia/Lymphoma, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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