TALMADGE E. KING, M.D.; MARVIN I. SCHWARZ, M.D.; ROBERT E. DREISIN, M.D.; DAVID S. PRATT, M.D.; A. N. THEOFILOPOULOS, M.D.
Presented in part at a meeting of the American Federation for Clinical Research, San Francisco, California, 1 May 1978.
▸Requests for reprints should be addressed to Talmadge E. King, Jr., M.D.; Veterans Administration Medical Center; 1055 Clermont Street; Denver, CO 80220.
KING TE, SCHWARZ MI, DREISIN RE, PRATT DS, THEOFILOPOULOS AN. Circulating Immune Complexes in Pulmonary Eosinophilic Granuloma. Ann Intern Med. 1979;91:397-399. doi: 10.7326/0003-4819-91-3-397
Download citation file:
Published: Ann Intern Med. 1979;91(3):397-399.
We analyzed serum from six patients with pulmonary eosinophilic granuloma for the presence of circulating immune complexes. These levels were correlated with the pulmonary histopathology and immunofluorescence findings. Levels of circulating immune complexes were elevated in five subjects. All of the subjects had an active cellular histology. Immunofluorescent studies showed granular deposits of IgG and complement (C3) in alveolar walls and blood vessels in all five patients. One subject had no detectable circulating immune complexes and showed a predominantly fibrotic pattern by light microscopy. In addition, immunofluorescence in this patient also showed no immunoglobulin or complement deposition within the lung tissue. These findings show that circulating immune complexlike activity is present in patients with cellular disease and suggest that their formation or deposition, or both, may contribute to the pathogenesis of pulmonary eosinophilic granuloma.
to gain full access to the content and tools.
Learn more about subscription options.
Register Now for a free account.
Pulmonary/Critical Care, Interstitial Lung Disease.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only