GERHARD BAUMANN, M.D.
To the editor: In the May 1979 issue Drs. Sheeler and Schumacher (1) report the cases of three patients who developed severe and symptomatic hyponatremia during prolonged (48-h) adrenocorticotropin (ACTH) tests. As pointed out by the authors, this problem was already recognized in the original report that introduced the 48-h ACTH test (2). Potential explanations for this complication offered by Sheeler and Schumacher are the known inability to excrete a water load in the patient with Addison's disease; and contamination of ACTH preparations with antidiuretic hormone (ADH). Water retention in hypoadrenal patients is due to glucocorticoid deficiency and can be
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BAUMANN G. Hyponatremia During Adrenocorticotropin (ACTH) Infusions. Ann Intern Med. 1979;91:499. doi: 10.7326/0003-4819-91-3-499_1
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Published: Ann Intern Med. 1979;91(3):499.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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