MICHAEL C. SMITH, M.D.; JAMES H. COOKE, M.D.; DONALD M. ZIMMERMAN, M.D.; JULIO J. BIRD, M.D.; B. LYNN FEASTER, M.D.; ROBERT E. MORRISON, M.D.; BERNHARD E. F. REIMANN
Two hundred forty previously healthy military personnel with nonstreptococcal upper respiratory infections were prospectively studied to define the incidence and clinicopathologic characteristics of possible virus-associated glomerulonephritis. Nine patients without preceding streptococcal infection had erythrocyte casts on urinalysis and glomerulonephritis on biopsy. Of these nine, four had a reduction in total hemolytic complement and five had serologic evidence of infection with adenovirus, influenza A, or influenza B. Initial renal biopsy showed either focal or diffuse mesangial proliferation in all nine, with mesangial C3 deposits in six specimens. Repeat biopsy in three showed histologic improvement or loss of immunofluorescent staining, or both. Sequential creatinine clearances were reduced to 74 to 90 mL/min · 1.73 m2 in five patients for the duration of follow-up. We conclude that nonstreptococcal upper respiratory infection is frequently associated with glomerulonephritis and that abnormal glomerular structure and decreased creatinine clearances may persist for at least 2 to 8 months.
Learn more about subscription options.
Register Now for a free account.
SMITH MC, COOKE JH, ZIMMERMAN DM, BIRD JJ, FEASTER BL, MORRISON RE, et al. Asymptomatic Glomerulonephritis After Nonstreptococcal Upper Respiratory Infections. Ann Intern Med. 1979;91:697–702. doi: 10.7326/0003-4819-91-5-697
Download citation file:
Published: Ann Intern Med. 1979;91(5):697-702.
Infectious Disease, Nephrology.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only