JOSE F. CARO, M.D.; JAIME H. CASTRO, M.D.; JOSEPH A. GLENNON, M.D.
Beta adrenergic agonists have been shown to stimulate parathyroid hormone (PTH) secretion from isolated parathyroid cells. This action can be blocked with the β-adrenergic antagonist propranolol. This response appears to differ from that due to calcium itself, since β-blockade does not alter tissue response to calcium and high calcium concentration does not suppress the response to β-adrenergic stimuli (1-3). Short-term in-vivo studies in animals (4) and humans (5) have also shown PTH responsiveness to β-adrenergic agonists and elimination of this response by propranolol.
We recently found that propranolol significantly decreased serum levels of PTH, alkaline phosphatase, and the incidence of
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CARO JF, CASTRO JH, GLENNON JA. Effect of Long-Term Propranolol Administration on Parathyroid Hormone and Calcium Concentration in Primary Hyperparathyroidism. Ann Intern Med. 1979;91:740-741. doi: 10.7326/0003-4819-91-5-740
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Published: Ann Intern Med. 1979;91(5):740-741.
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