JOSE F. CARO, M.D.; JAIME H. CASTRO, M.D.; JOSEPH A. GLENNON, M.D.
CARO JF, CASTRO JH, GLENNON JA. Effect of Long-Term Propranolol Administration on Parathyroid Hormone and Calcium Concentration in Primary Hyperparathyroidism. Ann Intern Med. 1979;91:740-741. doi: 10.7326/0003-4819-91-5-740
Download citation file:
Published: Ann Intern Med. 1979;91(5):740-741.
Beta adrenergic agonists have been shown to stimulate parathyroid hormone (PTH) secretion from isolated parathyroid cells. This action can be blocked with the β-adrenergic antagonist propranolol. This response appears to differ from that due to calcium itself, since β-blockade does not alter tissue response to calcium and high calcium concentration does not suppress the response to β-adrenergic stimuli (1-3). Short-term in-vivo studies in animals (4) and humans (5) have also shown PTH responsiveness to β-adrenergic agonists and elimination of this response by propranolol.
We recently found that propranolol significantly decreased serum levels of PTH, alkaline phosphatase, and the incidence of
Learn more about subscription options.
Register Now for a free account.
Cardiology, Coronary Risk Factors, Endocrine and Metabolism, HIV, Hypertension.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only