OLU OREDUGBA, M.D.; DEBESH C. MAZUMDAR, M.B., B.S.; JOHN S. MEYER, M.D.; HERBERT LUBOWITZ, M.D.
OREDUGBA O, MAZUMDAR DC, MEYER JS, LUBOWITZ H. Pulse Methylprednisolone Therapy in Idiopathic, Rapidly Progressive Glomerulonephritis. Ann Intern Med. 1980;92:504-506. doi: 10.7326/0003-4819-92-4-504
Download citation file:
Published: Ann Intern Med. 1980;92(4):504-506.
Idiopathic crescentic glomerulonephritis is associated with a 70% to 80% incidence of end-stage renal failure. Oral corticosteroid therapy in combination with immunosuppressive agents or anticoagulants has not altered the prognosis of this disease. We have seen five adults with idiopathic crescentic glomerulonephritis and treated them with intravenous methylprednisolone. Before therapy, the average serum creatinine concentration was 7.4 ± 1.3 mg/dL (chi-square ± SEM). This value declined to 2.0 ± 0.48 mg/dL within 4 weeks. All patients continue to maintain stable renal function over an average follow-up period of 19 months (range, 1.5 to 36 months). These data suggest that a prospective controlled trial of this therapy is warranted in the management of this entity.
Learn more about subscription options.
Register Now for a free account.
Chronic Kidney Disease, Nephrology.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only