ROBERT D. BRANDSTETTER, M.D.; DEXTER D. MAR, PHARM. D.
To the editor: In his otherwise excellent review of ibuprofen (1), Dr. Kantor has omitted adverse renal side effects when he discusses this drug's adverse effects. Over the last 2 years, significant attention has been directed towards deterioration of renal function caused by nonsteroidal anti-inflammatory drugs, including ibuprofen (2-5). The mechanism of the renal dysfunction is believed to involve renal prostaglandin synthetase inhibition with resulting alteration in renal hemodynamics (2).
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BRANDSTETTER RD, MAR DD. Side Effects of Ibuprofen. Ann Intern Med. 1980;92:569–570. doi: 10.7326/0003-4819-92-4-569_3
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Published: Ann Intern Med. 1980;92(4):569-570.
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