JAMES D. WEBSTER, M.D.; THOMAS F. PARKER, B.S. M.D.; AL C. ALFREY, M.D.; W. R. SMYTHE, Ph.D.; HIDEO KUBO, Ph.D.; GEORGE NEAL; ALAN R. HULL, M.D.
Nickel intoxication was observed in a group of 23 dialyzed patients when leaching of nickel-plated stainless steel water heater tank contaminated the dialysate. Symptoms occurred during and after dialysis at plasma nickel concentrations of approximately 3 mg/L. Symptoms included nausea (37 of 37), vomiting (31 of 37), weakness (29 of 37), headache (22 of 37), and palpitation (two of 37). Remission of symptoms occurred spontaneously, generally 3 to 13 hours after cessation of dialysis. The evidence indicated that the nickel became bound in the plasma after crossing the membrane, resulting in a higher concentration in the plasma than in the dialysate and preventing its removal by dialysis.
Learn more about subscription options.
Register Now for a free account.
WEBSTER JD, PARKER TF, ALFREY AC, SMYTHE WR, KUBO H, NEAL G, et al. Acute Nickel Intoxication by Dialysis. Ann Intern Med. 1980;92:631–633. doi: 10.7326/0003-4819-92-5-631
Download citation file:
Published: Ann Intern Med. 1980;92(5):631-633.
Emergency Medicine, Nephrology, Renal Replacement Therapy.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only