PAUL C. ROYCE, M.D., PH.D.; BRUCE R. MACKAY, M.D.; PETRINA M. DISABELLA, R.N., M.B.A.
ROYCE PC, MACKAY BR, DISABELLA PM. Serum Calcium After Therapeutic Head and Neck Irradiation. Ann Intern Med. 1980;93:146-147. doi: 10.7326/0003-4819-93-1-146
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Published: Ann Intern Med. 1980;93(1_Part_1):146-147.
To the editor: Hyperparathyroidism has been linked to therapeutic irradiation of the head and neck. This linkage is based on isolated case reports (1) and on series of patients with surgically proven hyperparathyroidism in which as many as 30% had received head-and-neck irradiation (2). While suggesting a cause and effect relation, these reports provide no information on the incidence of hyperparathyroidism in an irradiated cohort. We recently measured the serum calcium concentration in 214 persons with documented head-and-neck irradiation and in 243 control subjects as part of a program to evaluate the late effects of irradiation. Details of irradiation dose,
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