MICHAEL R. SIMON, M.D.
SIMON MR. Cimetidine and Immunologic Response. Ann Intern Med. 1980;93:152. doi: 10.7326/0003-4819-93-1-152_1
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Published: Ann Intern Med. 1980;93(1_Part_1):152.
To the editor: In the recently published paper "Cimetidine as an Immunomodulator: Chronic Mucocutaneous Candidiasis as a Model" (1), the authors report that their patients with chronic mucocutaneous candidiasis developed positive delayed hypersensitivity skin tests while receiving cimetidine. In neither this paper nor in an earlier description of the same patients (2) are results of immediate hypersensitivity skin tests with candidal antigen reported. Immunologic histamine release induced by cutaneous injection of antigen may suppress the delayed hypersensitivity skin response to that antigen (3). Nine of 10 patients with chronic mucocutaneous candidiasis reported by Kirkpatrick and Smith (4) showed immediate hypersensitivity
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