SHELDON E. SCHWARTZ, M.D.; STEVEN P. SIEGELBAUM, M.D.; THOMAS L. FAZIO, M.D.; CHARLENE HUBBELL, B.S.; JOHN B. HENRY, M.D.
Grant support: in part by grants AM 21088 and AI 52513 from the National Institutes of Health.
▸Requests for reprints should be addressed to Sheldon E. Schwartz, M.D.; Department of Medicine, State University Hospital, 750 East Adams Street; Syracuse, NY 13210.
SCHWARTZ S., SIEGELBAUM S., FAZIO T., HUBBELL C., HENRY J.; Regional Enteritis: Evidence for Genetic Transmission by HLA Typing. Ann Intern Med. 1980;93:424-427. doi: 10.7326/0003-4819-93-3-424
Download citation file:
Published: Ann Intern Med. 1980;93(3):424-427.
Lymphocytes from kindreds containing five sibling pairs affected with regional enteritis were typed to ascertain the association between histocompatibility leukocyte antigens (HLA)-A and -B and regional enteritis. Also, the frequency of HLA antigens in 22 patients with nonfamilial cases of regional enteritis was compared to the frequency in 402 normal blood donors. No HLA haplotype was found in more than one kindred, and no HLA antigen was more prevalent in nonfamilial cases of regional enteritis than in the normal population. In the five affected sibling pairs, four shared both haplotypes (HLA identical), and one shared one haplotype. Only one unaffected sibling shared two haplotypes with an affected proband. The high frequency of HLA identity in affected siblings and the low frequency of identity in unaffected siblings suggest linkage between the histocompatibility locus and the development of regional enteritis. There appears to be a genetic component in kindreds with regional enteritis.
to gain full access to the content and tools.
Learn more about subscription options.
Register Now for a free account.
Gastroenterology/Hepatology, Inflammatory Bowel Disease.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only