WENDY E. HOY, M.B., B.S.; ALEJANDRO RIVERO, M.D.; MATTHEW G. MARIN, M.D.; FREDRIC RIEDERS, Ph. D.
Hemoperfusion with Amberlite XAD-4 resin (X-R004 cartridge; Extracorporeal Medical Specialties, Inc., King of Prussia, Pennsylvania) (1) removes meprobamate from plasma and produces better drug clearance than does charcoal hemoperfusion (2). We report here two life-saving XAD-4 hemoperfusions in a patient with a massive meprobamate overdose in which the efficient calculated extraction of drug was confirmed by subsequent recovery of a large quantity of meprobamate from the used cartidges.
A 39-year-old man ingested 200 g of meprobamate and a quantity of other drugs. His stomach contained many pill fragments, and charcoal slurry and magnesium citrate were instilled. He became comatose and
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HOY WE, RIVERO A, MARIN MG, RIEDERS F. Resin Hemoperfusion for Treatment of a Massive Meprobamate Overdose. Ann Intern Med. 1980;93:455–456. doi: 10.7326/0003-4819-93-3-455
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Published: Ann Intern Med. 1980;93(3):455-456.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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