HELEN C. MITCHELL, M.D.; ROBERT M. GRAHAM, M.D.; WILLIAM A. PETTINGER, M.D.
MITCHELL HC, GRAHAM RM, PETTINGER WA. Renal Function During Long-Term Treatment of Hypertension with Minoxidil: Comparison of Benign and Malignant Hypertension. Ann Intern Med. 1980;93:676-681. doi: 10.7326/0003-4819-93-5-676
Download citation file:
Published: Ann Intern Med. 1980;93(5):676-681.
We examined the effect of long-term blood pressure control on renal function in 41 patients with refractory hypertension by using minoxidil, sympathetic suppressants, and diuretics continuously for 6 months to 7½ years. In 15 of 32 patients with benign hypertension, the serum creatinine concentration increased by more than 1 mg/dL, with nine of 15 requiring hemodialysis. Analysis of 1/serum creatinine versus time plots indicated that use of minoxidil delayed the onset of end-stage renal failure in some patients for up to 6 years. In the remaining 17 patients with benign hypertension, renal function remained stable with no decreases greater than 2 mg/dL. Four of nine patients presenting with malignant hypertension had marked and sustained improvement in renal function, although three initially required hemodialysis. The mean serum creatinine concentration in these four patients fell from 9.7 to 2.9 mg/dL. Thus, impressive renal functional improvement may occur with minoxidil use in some patients with malignant hypertension.
Learn more about subscription options.
Register Now for a free account.
Cardiology, Geriatric Medicine, Nephrology, Hypertension, Coronary Risk Factors.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only