WILLIAM A. BLATTNER, M.D.; JUDY E. GARBER, B.S.; DEAN L. MANN, M.D.; ELISABETH A. McKEEN, M.D.; ROBIN HENSON, B.S.; DEBORAH B. McGUIRE, B.S.N.; WILLIAM B. FISHER, M.D.; ARTHUR W. BAUMAN, M.D.; LYNN R. GOLDIN, Ph.D.; JOSEPH F. FRAUMENI Jr., M.D.
We diagnosed Waldenstrom's macroglobulinemia in a father and three offspring. Clinical and subclinical autoimmune disorders occurred excessively in the family. The HLA haplotype A2, B8, DRw3 was detected in all patients with Waldenstrom's macroglobulinemia and all but one family member with autoimmune manifestations. A lod score [log odds] of 4.86 favors linkage to the HLA complex of a gene predisposing to lymphoproliferative and autoimmune disorders. Associated with this HLA haplotype were the B-cell alloantigens Ia-172 and 350, previously reported in patients with the lymphoma-prone sicca syndrome.
Learn more about subscription options.
Register Now for a free account.
BLATTNER WA, GARBER JE, MANN DL, McKEEN EA, HENSON R, McGUIRE DB, et al. Waldenström's Macroglobulinemia and Autoimmune Disease in a Family. Ann Intern Med. 1980;93:830–832. doi: 10.7326/0003-4819-93-6-830
Download citation file:
Published: Ann Intern Med. 1980;93(6):830-832.
Hematology/Oncology, Leukemia/Lymphoma, Rheumatology.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only