IRENE GAVRAS, M. D.; LOUIS G. GRAFF, M.D.; BURTON D. ROSE, M.D.; JOHN M. McKENNA, M.D.; HANS R. BRUNNER, M.D.; HARALAMBOS GAVRAS, M.D.
GAVRAS I, GRAFF LG, ROSE BD, McKENNA JM, BRUNNER HR, GAVRAS H. Fatal Pancytopenia Associated with the Use of Captopril. Ann Intern Med. 1981;94:58-59. doi: 10.7326/0003-4819-94-1-58
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Published: Ann Intern Med. 1981;94(1):58-59.
Chronic inhibition of the angiotensin-converting enzyme has been used successfully in treating hypertension and congestive cardiac failure (1-4) over the past 3 years. The only oral angiotensin-converting enzyme inhibitor presently available for clinical use, captopril (Capoten, E. R. Squibb & Sons, Inc., Princeton, New Jersey), has been associated with a number of adverse reactions. These include skin rashes, sometimes preceded by fever, often accompanied by eosinophilia and lymphopenia; proteinuria, usually observed in patients with primary renal parenchymal disease; alteration or loss of taste; and recently, four cases of leukopenia with agranulocytosis (5-8). All these were transient and reversible by decreasing
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Cardiology, Hematology/Oncology, Infectious Disease, Nephrology, HIV.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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