DARRELL R. ABERNETHY, M.D., Ph.D.; DAVID J. GREENBLATT, M.D.; RICHARD I. SHADER, M.D.
True physiologic addiction to diazepam has been reliably described in isolated cases by documentation of a physical withdrawal syndrome characterized by agitation, tachycardia, and diaphoresis and, rarely, hallucinations, psychosis, and seizures (1). Although usually occurring after prolonged use of high doses, in one case a withdrawal syndrome occurred after abrupt withdrawal of diazepam after long-term use in a usual therapeutic dose (2). The present report describes a case of diazepam withdrawal syndrome after long-term ingestion of extremely high doses. The case was documented and the patient effectively treated with propranolol.
Plasma levels of diazepam and desmethyldiazepam, the biologically active demethylated
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ABERNETHY DR, GREENBLATT DJ, SHADER RI. Treatment of Diazepam Withdrawal Syndrome with Propranolol. Ann Intern Med. 1981;94:354–355. doi: 10.7326/0003-4819-94-3-354
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Published: Ann Intern Med. 1981;94(3):354-355.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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