GARY E. WHEELER, M.D.
WHEELER G.; Cyclophosphamide-Associated Leukemia in Wegener's Granulomatosis. Ann Intern Med. 1981;94:361-362. doi: 10.7326/0003-4819-94-3-361
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Published: Ann Intern Med. 1981;94(3):361-362.
The efficacy of cyclophosphamide therapy in Wegener's granulomatosis is well established. Recent reports have suggested other vasculitides may also be responsive to this drug (1, 2). Long-term follow-up studies of patients with Wegener's granulomatosis have not found significant toxicity from continuous cyclophosphamide therapy (3, 4). A patient with Wegener's granulomatosis in whom the development of acute leukemia appears related to cyclophosphamide therapy is described here.
A 53-year-old woman was seen in November 1978 with a 6-week history of arthritis of the second proximal interphalangeal joint of the left hand, the third proximal interphalangeal joint of the right foot, a 7.7
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Hematology/Oncology, Nephrology, Pulmonary/Critical Care, Rheumatology, Autoimmune Kidney Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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